The GOT, GPT, and LDH levels were measured of 117 samples of cerebrospinal fluid from 94 patients who had been admitted to the Department of Internal Medicine, Kyung Hee University Hospital, with acute cerebrovascular accidents and cerebrospinal infection from April 1974 up to September 1974. The patients were composed of 28 cases of cerebral thrombosis, I5 of subarchnoid hemorrhage, 28 of intracerebral hemorrhage, 6 of central nervous system infection, and 21 of miscellaneous diseases. Enzyme levels of 10 preoperative patients with other diseases were also measured as a control group.
The results were analyzed with regard to the etiology and the prognosis of the disease. Some possible explanation enzymatic elevations in CSF were discussed.
The results are as follow:
1. Cerebrospinal fluid GOT, GPT, and LDH were generally elevated in cerebrovascular diseases and CNS infections.
2. Cerebrospinal fluid GOT was elevated most prominently in intracerebral hemorrage.
3. Cerebrospinal fluid LDH was elevated markedly in suppurative meningitis.
4. There were no correlation between the level of enzymes and the prognosis of the diseases.
It seems possible that diffusion of serum enzyme into CSF would be attributable to the enzyme elevation in CSF in various CNS diseases.
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